How it Works

Each ingestible SITZMARKS® capsule contains 24 radiopaque markers that are visible throughout the digestive tract via X-ray. The markers are available in three different shapes, O-Ring, Double D and Tri-Chamber, to accommodate both the simple and segmental testing methods.

double o-ring


One or more low dose, flat plate abdominal X-ray occurs in the week following capsule ingestion to determine the extent of the markers elimination. The location of the markers in the patient’s digestive tract assists in the diagnosis of many GI conditions, including:

  • Bowel Obstruction
  • Colonic Inertia
  • Constipation
  • Diverticular Disease
  • Functional Outlet Obstruction
  • Hemorrhoids
  • Hypomotility
  • Irritable Bowel Syndrome (IBS)

Examples of SITZMARKS® studies:

  • "Chronic Constipation: Diagnosis and Treatment," Endoscopy Review, November/December 1987, Ogorek, C.P., Reynolds, J.C.
  • "Chronic Constipation," Postgraduate Advances in Colorectal Surgery, 1989, 1(12):1-22, Wexner, S.D. Jagelman, D.G.
  • "Streamlining the Management of Defecation Disorders," Diseases of the Colon & Rectum, September 1990, Berman, I.R., et al. (
  • "Colectomy for Constipation: Physiologic Investigation is the Key to Success," Diseases of the Colon & Rectum, 1991 34:851-6, Wexner, S.D., Daniel, N., Jagelman, D.G. (
  • "Outpatient Protocol for Biofeedback Therapy of Pelvic Floor Outlet Obstruction," Diseases of the Colon & Rectum, January 1992, Fleshman, J.W., et al. (
  • "What is the Meaning of Colorectal Transit Time Measurement," Diseases of the Colon & Rectum, August 1992, Bouchoucha, M., Devroede, G., et al. (